Articles
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Citation: AIDS Research and Therapy 2007 4:5
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Trends in the HIV related hospital admissions in the HAART era in Barbados, 2004–2006
To investigate the reasons for hospitalizations and its outcome in the era of HAART in Barbados. This report also describes the profile of the HIV infected persons who are hospitalized in the HAART era.
Citation: AIDS Research and Therapy 2007 4:4 -
Retroviral rebound syndrome after treatment discontinuation in a 15 year old girl with HIV attracted through mother-to-child transmission: case report
A case of a 15 year old girl with retroviral rebound syndrome after discontinuation of highly active antiretroviral treatment (HAART) due to side effects is presented. The patient was transmitted with HIV at b...
Citation: AIDS Research and Therapy 2007 4:3 -
Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338)
The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children. We evaluated drug resistance mutations at 39 codon sites ...
Citation: AIDS Research and Therapy 2007 4:2 -
Determining eligibility for antiretroviral therapy in resource-limited settings using total lymphocyte counts, hemoglobin and body mass index
CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs)...
Citation: AIDS Research and Therapy 2007 4:1 -
Use of taste-masking product, FLAVORx, to assist Thai children to ingest generic antiretrovirals
We evaluated whether FLAVORx helped thirty Thai children take opened capsule, crushed tablets and liquid generic ARVs with more ease. All children had excellent adherence, evaluated by PACTG Standard Internati...
Citation: AIDS Research and Therapy 2006 3:30 -
Post-exposure prophylaxis for SIV revisited: Animal model for HIV prevention
A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treat...
Citation: AIDS Research and Therapy 2006 3:29 -
HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission
HLA-G gene is a non-classical MHC class 1 molecule that is highly expressed in the trophoblast at the maternal-fetal interface. In an attempt to elucidate possible immunological mechanisms facilitating protection...
Citation: AIDS Research and Therapy 2006 3:28 -
HIV among pregnant women in Moshi Tanzania: the role of sexual behavior, male partner characteristics and sexually transmitted infections
Women continue to be disproportionately affected by HIV in Tanzania, and factors contributing to this situation need to be identified. The objective of this study was to determine social, behavioral and biolog...
Citation: AIDS Research and Therapy 2006 3:27 -
Comparison of capillary based microflurometric assay for CD4+ T cell count estimation with dual platform Flow cytometry
The CD4+ T cell count estimation is an important monitoring tool for HIV disease progression and efficacy of anti-retroviral treatment (ART). Due to availability of ART at low cost in developing countries, que...
Citation: AIDS Research and Therapy 2006 3:26 -
Microbicides 2006 conference
Current HIV/AIDS statistics show that women account for almost 60% of HIV infections in Sub-Saharan Africa. HIV prevention tools such as male and female condoms, abstinence and monogamy are not always feasible...
Citation: AIDS Research and Therapy 2006 3:25 -
Niekerk Anton A, Kopelman Loretta M: Ethics and AIDS in Africa: The Challenge to our Thinking Walnut Creek, California: Left Coast Press; 2005. 222 pages, ISBN 1-59874-070-9
Citation: AIDS Research and Therapy 2006 3:24 -
Prevention for those who have freedom of choice – or among the choice-disabled: confronting equity in the AIDS epidemic
With the exception of post-exposure prophylaxis for reported rape, no preventive strategy addresses the choice disabled – those who might like to benefit from AIDS prevention but who are unable to do so becaus...
Citation: AIDS Research and Therapy 2006 3:23 -
Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals
Despite multiple sexual exposure to HIV-1 virus, some individuals remain HIV-1 seronegative (exposed seronegative, ESN). The mechanisms underlying this resistance remain still unclear, although a multifactoria...
Citation: AIDS Research and Therapy 2006 3:22 -
Cytotoxic T cell recognition of an HIV-1 reverse transcriptase variant peptide incorporating the K103N drug resistance mutation
During HIV-1 infection, cytotoxic T cell (CTL) responses exert strong selective pressure on the replicating virus population. Here we report evidence for T cell activity against the drug resistant K103N region...
Citation: AIDS Research and Therapy 2006 3:21 -
Predicting AIDS-related events using CD4 percentage or CD4 absolute counts
The extent of immunosuppression and the probability of developing an AIDS-related complication in HIV-infected people is usually measured by the absolute number of CD4 positive T-cells. The percentage of CD4 p...
Citation: AIDS Research and Therapy 2006 3:20 -
The effect of different combination therapies on oxidative stress markers in HIV infected patients in cameroon
The study assessed the effect of some highly active antiretroviral therapies (HAART), used in the management of HIV/AIDS in Cameroon, on oxidative stress markers such as malondialdehyde (as TBARs), albumin, pr...
Citation: AIDS Research and Therapy 2006 3:19 -
IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
Diminished IL-2 production and lack of effector differentiation have been reported for HIV-specific T cells. In this study, we examined the prevalence of these phenomena using 8-color cytokine flow cytometry, ...
Citation: AIDS Research and Therapy 2006 3:18 -
Body image in women with HIV: a cross-sectional evaluation
HIV lipodystrophy syndrome is a recognized complication of potent antiretroviral therapy and is characterized by often dramatic changes in various body fat stores, both central and peripheral. Given prior find...
Citation: AIDS Research and Therapy 2006 3:17 -
A placebo-controlled pilot study of intensification of antiretroviral therapy with mycophenolate mofetil
We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia.
Citation: AIDS Research and Therapy 2006 3:16 -
Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme
The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been show...
Citation: AIDS Research and Therapy 2006 3:15 -
Aboriginal status is a prognostic factor for mortality among antiretroviral naïve HIV-positive individuals first initiating HAART
Although the impact of Aboriginal status on HIV incidence, HIV disease progression, and access to treatment has been investigated previously, little is known about the relationship between Aboriginal ethnicity...
Citation: AIDS Research and Therapy 2006 3:14 -
A nucleolar localizing Rev binding element inhibits HIV replication
The Rev protein of the human immunodeficiency virus (HIV) facilitates the nuclear export of intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through the nucleolus and shuttl...
Citation: AIDS Research and Therapy 2006 3:13 -
Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects
Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time...
Citation: AIDS Research and Therapy 2006 3:12 -
Efavirenz use during pregnancy and for women of child-bearing potential
Efavirenz is the preferred non-nucleoside reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. For women of childbearing potential, advantages of efavirenz are balanced by...
Citation: AIDS Research and Therapy 2006 3:11 -
Antiretroviral therapy at a district hospital in Ethiopia prevents death and tuberculosis in a cohort of HIV patients
Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuber...
Citation: AIDS Research and Therapy 2006 3:10 -
Randomized controlled trial of Hepatitis B virus vaccine in HIV-1-infected patients comparing two different doses
Co-infection with hepatitis B virus (HBV) and human immunodeficiency virus (HIV) is not infrequent as both share same route of exposure. The risk of developing chronic hepatitis B virus is 6%, in general popul...
Citation: AIDS Research and Therapy 2006 3:9 -
LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells
Co-infections of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (M. Tb) are steadily increasing and represent a major health crisis in many developing countries. Both pathogens individually sti...
Citation: AIDS Research and Therapy 2006 3:8 -
Butera Salvatore T: HIV Chemotherapy: a Critical Review Norfolk: Caister Academic Press; 2005. 309 pages, ISBN 0-9542464-9-7
Citation: AIDS Research and Therapy 2006 3:7 -
Assessing the effect of HAART on change in quality of life among HIV-infected women
The impact of highly active antiretroviral therapy (HAART) on health-related quality of life (QOL) of HIV-1 infected individuals in large prospective cohorts has not been well studied.
Citation: AIDS Research and Therapy 2006 3:6 -
Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects
Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individual...
Citation: AIDS Research and Therapy 2006 3:5 -
Phase I safety study of 0.5% PRO 2000 vaginal Gel among HIV un-infected women in Pune, India
The objective of this study was to evaluate the safety of twice daily, intra-vaginal use of 0.5% PRO 2000 Gel for fourteen days in HIV un-infected women at lower as well as higher risk for HIV acquisition, in ...
Citation: AIDS Research and Therapy 2006 3:4 -
Absence of seroreversion in 80 HAART-treated HIV-1 seropositive patients with at least five-years undetectable plasma HIV-1 viral load
Partial or complete seroreversion for HIV-1, or incomplete antibody evolution are relatively rare events that have so far only been described in patients treated with HAART early after virus infection. Whether...
Citation: AIDS Research and Therapy 2006 3:3 -
Expanding access to HIV prevention
Citation: AIDS Research and Therapy 2006 3:2 -
Review of "The Twelfth West Coast Retrovirus Meeting" and "The Twenty-third Annual Symposium on Nonhuman Primate Models for AIDS"
Two recent meetings held on the west coast of the USA highlighted current work being done in the field of retrovirology and AIDS. The meetings, "The Twelfth West Coast Retrovirus Meeting" (Palm Springs CA; Oct...
Citation: AIDS Research and Therapy 2006 3:1 -
Scutellaria baicalensis decreases ritonavir-induced nausea
Protease inhibitors, particularly ritonavir, causes significant gastrointestinal disturbances such as nausea, even at low doses. This ritonavir-induced nausea could be related to its oxidative stress in the gu...
Citation: AIDS Research and Therapy 2005 2:12 -
HIV in semen: Still more to be learned
Citation: AIDS Research and Therapy 2005 2:11 -
Barriers to the implementation of programs for the prevention of mother-to-child transmission of HIV: A cross-sectional survey in rural and urban Uganda
Implementation of programs for the prevention of mother-to-child transmission (PMTCT) of HIV faces a variety of barriers and challenges. The assessment of these challenges has generally been conducted in large...
Citation: AIDS Research and Therapy 2005 2:10 -
Human immunodeficiency virus type-1 episomal cDNA in semen
Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor crypt...
Citation: AIDS Research and Therapy 2005 2:9 -
HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors
RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture. We previously reported m...
Citation: AIDS Research and Therapy 2005 2:8 -
Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors
Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human ...
Citation: AIDS Research and Therapy 2005 2:7 -
Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection
The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid (CSF) concentrations of the light chain of the neurofilament protein (NFL) can serve as a sensitive indicato...
Citation: AIDS Research and Therapy 2005 2:6 -
Evaluation of the proficiency of trained non-laboratory health staffs and laboratory technicians using a rapid and simple HIV antibody test
In Cambodia, nearly half of pregnant women attend antenatal care (ANC), which is an entry point of services for prevention of mother-to-child transmission of HIV (PMTCT). However, most of ANC services are prov...
Citation: AIDS Research and Therapy 2005 2:5 -
Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: a systematic review of randomized trial including more than 2800 women
Observational studies have suggested that low serum vitamin levels are associated with increased mother-to-child transmission (MTCT) of HIV and increased preterm delivery. We aimed to determine the efficacy of...
Citation: AIDS Research and Therapy 2005 2:4 -
Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?
Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a u...
Citation: AIDS Research and Therapy 2005 2:3 -
Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot...
Citation: AIDS Research and Therapy 2005 2:2 -
HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector
RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs agains...
Citation: AIDS Research and Therapy 2005 2:1 -
Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages
RNA based antiviral approaches against HIV-1 are among the most promising for long-term gene therapy. These include ribozymes, aptamers (decoys), and small interfering RNAs (siRNAs). Lentiviral vectors are ide...
Citation: AIDS Research and Therapy 2004 1:2 -
What does the marriage of Open Access with online publication bring?
Open Access online publishing is the trend of the future for unrestricted rapid and international dissemination of knowledge. Several journals are published on acquired immune deficiency syndrome (AIDS) resear...
Citation: AIDS Research and Therapy 2004 1:1