Articles

Assessing the effect of HAART on change in quality of life among HIV-infected women

The impact of highly active antiretroviral therapy (HAART) on health-related quality of life (QOL) of HIV-1 infected individuals in large prospective cohorts has not been well studied.

Authors: Chenglong Liu, Kathleen Weber, Esther Robison, Zheng Hu, Lisa P Jacobson and Stephen J Gange

Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects

Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individual...

Authors: Vishwanath Venketaraman, Tatanisha Rodgers, Rafael Linares, Nancy Reilly, Shobha Swaminathan, David Hom, Ariel C Millman, Robert Wallis and Nancy D Connell

Phase I safety study of 0.5% PRO 2000 vaginal Gel among HIV un-infected women in Pune, India

The objective of this study was to evaluate the safety of twice daily, intra-vaginal use of 0.5% PRO 2000 Gel for fourteen days in HIV un-infected women at lower as well as higher risk for HIV acquisition, in ...

Authors: Joshi Smita, Dutta Soma, Bell Beverly, Profy Albert, Kuruc JoAnn, Gai Fang, Cianciola Missy, Soto-Torres Lydia, Panchanadikar Anjali, Risbud Arun, Mehendale Sanjay and Reynolds Steven J

Absence of seroreversion in 80 HAART-treated HIV-1 seropositive patients with at least five-years undetectable plasma HIV-1 viral load

Partial or complete seroreversion for HIV-1, or incomplete antibody evolution are relatively rare events that have so far only been described in patients treated with HAART early after virus infection. Whether...

Authors: Marion Cornelissen, Suzanne Jurriaans, Jan M Prins, Margreet Bakker and Antoinette C van der Kuyl

Expanding access to HIV prevention

Authors: Helene D Gayle

Review of "The Twelfth West Coast Retrovirus Meeting" and "The Twenty-third Annual Symposium on Nonhuman Primate Models for AIDS"

Two recent meetings held on the west coast of the USA highlighted current work being done in the field of retrovirology and AIDS. The meetings, "The Twelfth West Coast Retrovirus Meeting" (Palm Springs CA; Oct...

Authors: J Scott Cairns

Scutellaria baicalensis decreases ritonavir-induced nausea

Protease inhibitors, particularly ritonavir, causes significant gastrointestinal disturbances such as nausea, even at low doses. This ritonavir-induced nausea could be related to its oxidative stress in the gu...

Authors: Han Aung, Sangeeta Mehendale, Wei-Tien Chang, Chong-Zhi Wang, Jing-Tian Xie and Chun-Su Yuan

HIV in semen: Still more to be learned

Authors: Pietro L Vernazza

Barriers to the implementation of programs for the prevention of mother-to-child transmission of HIV: A cross-sectional survey in rural and urban Uganda

Implementation of programs for the prevention of mother-to-child transmission (PMTCT) of HIV faces a variety of barriers and challenges. The assessment of these challenges has generally been conducted in large...

Authors: Francis Bajunirwe and Michael Muzoora

Human immunodeficiency virus type-1 episomal cDNA in semen

Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor crypt...

Authors: Chong Xu, Joseph A Politch, Kenneth H Mayer and Deborah J Anderson

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors

RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture. We previously reported m...

Authors: Timothy S Fisher, Pheroze Joshi and Vinayaka R Prasad

Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors

Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human ...

Authors: Sandra Siegert, Sonja Thaler, Ralf Wagner and Barbara S Schnierle

Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection

The neurofilament is a major structural component of myelinated axons. Increased cerebrospinal fluid (CSF) concentrations of the light chain of the neurofilament protein (NFL) can serve as a sensitive indicato...

Authors: Magnus Gisslén, Lars Rosengren, Lars Hagberg, Steven G Deeks and Richard W Price

Evaluation of the proficiency of trained non-laboratory health staffs and laboratory technicians using a rapid and simple HIV antibody test

In Cambodia, nearly half of pregnant women attend antenatal care (ANC), which is an entry point of services for prevention of mother-to-child transmission of HIV (PMTCT). However, most of ANC services are prov...

Authors: Koum Kanal, Thai Leang Chou, Ly Sovann, Yasuo Morikawa, Yumi Mukoyama and Kazuhiro Kakimoto

Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: a systematic review of randomized trial including more than 2800 women

Observational studies have suggested that low serum vitamin levels are associated with increased mother-to-child transmission (MTCT) of HIV and increased preterm delivery. We aimed to determine the efficacy of...

Authors: Edward J Mills, Ping Wu, Dugald Seely and Gordon H Guyatt

Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?

Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a u...

Authors: Karen S Slobod, Chris Coleclough, Scott A Brown, John Stambas, Xiaoyan Zhan, Sherri Surman, Bart G Jones, Amy Zirkel, Pamela J Freiden, Brita Brown, Robert Sealy, Mattia Bonsignori and Julia L Hurwitz

Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot...

Authors: Heather A Baird, Andre J Marozsan, Michael M Lederman, Alan Landay, Donna Mildvan, Daniel R Kuritzkes, Harold A Kessler and Eric J Arts

HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector

RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs agains...

Authors: Joseph Anderson and Ramesh Akkina

Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages

RNA based antiviral approaches against HIV-1 are among the most promising for long-term gene therapy. These include ribozymes, aptamers (decoys), and small interfering RNAs (siRNAs). Lentiviral vectors are ide...

Authors: Akhil Banerjea, Ming-Jie Li, Leila Remling, John Rossi and Ramesh Akkina

What does the marriage of Open Access with online publication bring?

Open Access online publishing is the trend of the future for unrestricted rapid and international dissemination of knowledge. Several journals are published on acquired immune deficiency syndrome (AIDS) resear...

Authors: Kailash C Gupta