Characteristics | All study participants (n = 500) | HIV-infected participants with T2D (n = 59, 11.8%) | HIV-uninfected participants with T2D (n = 441, 88.2%) | P-value |
---|---|---|---|---|
Age, years | 48 (39–58) | 53 (46–57) | 47 (39–58) | 0.01 |
Females | 283 (56.6) | 37 (62.7) | 246 (55.8) | 0.31 |
Markers of adiposity BMI, kg/m2 | 27.4 (23.6–31.4) | 25.8 (23.3–29.6) | 27.7 (23.6–31.6) | 0.06 |
WC, cm | 96.0 (87.0-104.8) | 94.0 (86.0-101.5) | 96.0 (87.5–105.0) | 0.42 |
HC, cm | 103.0 (96.0-111.5) | 97.8 (91.0-106.0) | 104.0 (96.0-112.0) | 0.002 |
WHR | 0.92 (0.88–0.96) | 0.95 (0.91–0.99) | 0.92 (0.87–0.96) | 0.007 |
Visceral fat level on BIA | 9 (7–12) | 8 (6–11) | 10 (7–12) | < 0.001 |
Metabolic markers HbA1c, % | 10.3 (7.7–12.5) | 11.3 (8.5–12.7) | 10.2 (7.7–12.5) | 0.16 |
HbA1c, mmol/mol | 90 (61–113) | 100 (69–115) | 88 (60–113) | 0.16 |
Fasting blood glucose, mmol/l | 8.6 (6.2–13.4) | 9.0 (5.8–14.8) | 8.6 (6.2–13.1) | 0.58 |
Total cholesterol, mmol/l | 4.0 (3.3-5.0) | 3.9 (3.2–5.1) | 4.1 (3.3-5.0) | 0.78 |
High-density lipoprotein cholesterol, mmol/l | 0.95 (0.74–1.20) | 0.89 (0.70–1.20) | 0.96 (0.75–1.20) | 0.26 |
Triglycerides, mmol/l | 1.3 (1.0-1.8) | 1.5 (1.1–2.1) | 1.3 (1.0-1.8) | 0.06 |
Low-density lipoprotein cholesterol, mmol/l | 2.6 (1.9–3.4) | 2.4 (1.9–3.3) | 2.6 (1.9–3.4) | 0.31 |
Non-high-density lipoprotein cholesterol, mmol/l | 3.0 (2.4–3.8) | 2.9 (2.4–3.9) | 3.0 (2.4–3.8) | 0.80 |
Markers of pancreatic beta-cell function Fasting serum C-peptide, ng/ml | 1.4 (0.8–2.1) | 1.5 (1.0–2.0) | 1.4 (0.8–2.1) | 0.50 |
30-minute serum C-peptide, ng/ml (post-OGTT) | 2.1 (1.1–3.3) | 2.1 (1.5-3.0) | 2.1 (1.1–3.4) | 0.94 |
120-minute serum C-peptide, ng/ml (post-OGTT) | 2.8 (1.5–4.8) | 2.7 (1.6-4.0) | 2.9 (1.5–4.9) | 0.77 |
Fasting insulin, µU/ml | 5.9 (3.0-10.6) | 6.7 (4.2–9.8) | 5.8 (2.9–10.7) | 0.35 |
Oral IGI, µU/mmol | 1.31 (0.47–3.85) | 1.06 (0.40–3.56) | 1.38 (0.48–3.96) | 0.48 |
HOMA2- %B | 43.1 (20.7–77.6) | 39.2 (15.4–77.8) | 43.5 (22.3–77.2) | 0.85 |
Marker of insulin resistance HOMA2-IR | 1.21 (0.77–2.03) | 1.24 (0.82–2.11) | 1.20 (0.76–2.01) | 0.83 |