Table 2 The information and allele frequencies of the 42 tSNPs in cases and controls
SNP | Gene | CHR a | Risk Allele | Case | Control | P value | OR (95%CI) | P value b for HWET c |
|---|---|---|---|---|---|---|---|---|
rs6780250 | ATR | 3 | C | 528(0.501) | 518(0.490) | 0.602 | 1.046(0.882–1.241) | 0.236 |
rs145813077 | ATR | 3 | C | 32(0.030) | 31(0.029) | 0.892 | 1.035(0.627–1.709) | 0.488 |
rs77147770 | ATR | 3 | T | 45(0.044) | 33(0.031) | 0.146 | 1.402(0.888–2.216) | 0.457 |
rs75069062 | ATR | 3 | T | 32(0.031) | 32(0.030) | 0.950 | 1.016(0.618–1.671) | 0.472 |
rs200611164 | ATR | 3 | A | 54(0.052) | 50(0.048) | 0.658 | 1.093(0.737–1.622) | 0.251 |
rs34660854 | ATR | 3 | A | 242(0.229) | 205(0.194) | 0.049 | 1.234(1.001–1.521) | 0.249 |
rs10804682 | ATR | 3 | G | 1016(0.960) | 1009(0.954) | 0.453 | 1.175(0.771–1.789) | 0.264 |
rs73240305 | ATR | 3 | A | 957(0.906) | 946(0.894) | 0.353 | 1.144(0.861–1.522) | 0.974 |
rs75368165 | ATR | 3 | A | 224(0.213) | 181(0.173) | 0.020 | 1.296(1.042–1.611) | 0.101 |
rs4683425 | ATR | 3 | A | 981(0.956) | 963(0.944) | 0.212 | 1.290(0.865–1.925) | 0.238 |
rs77627941 | ATR | 3 | A | 127(0.122) | 106(0.101) | 0.132 | 1.233(0.938–1.621) | 0.759 |
rs2227929 | ATR | 3 | G | 433(0.410) | 402(0.381) | 0.168 | 1.131(0.950–1.346) | 0.924 |
rs68065420 | ATR | 3 | A | 385(0.367) | 352(0.334) | 0.116 | 1.155(0.965–1.381) | 0.811 |
rs117312638 | ATR | 3 | T | 89(0.084) | 86(0.081) | 0.813 | 1.038(0.762–1.415) | 0.145 |
rs35514263 | ATR | 3 | T | 148(0.141) | 145(0.138) | 0.796 | 1.033(0.807–1.323) | 0.706 |
rs1057733 | Chk1 | 11 | T | 645(0.613) | 620(0.587) | 0.223 | 1.114(0.936–1.327) | 0.857 |
rs558351 | Chk1 | 11 | C | 637(0.603) | 620(0.587) | 0.451 | 1.069(0.899–1.272) | 0.857 |
rs12576279 | Chk1 | 11 | T | 927(0.880) | 918(0.873) | 0.632 | 1.065(0.822–1.381) | 0.834 |
rs3731424 | Chk1 | 11 | T | 104(0.099) | 92(0.087) | 0.339 | 1.154(0.8599-1.55) | 0.590 |
rs537046 | Chk1 | 11 | A | 811(0.771) | 797(0.756) | 0.426 | 1.085(0.887–1.327) | 0.049 |
rs10893405 | Chk1 | 11 | A | 865(0.821) | 863(0.816) | 0.766 | 1.034(0.829–1.290) | 0.251 |
rs3731438 | Chk1 | 11 | A | 878(0.831) | 862(0.815) | 0.315 | 1.122(0.897–1.403) | 0.363 |
rs540436 | Chk1 | 11 | T | 195(0.186) | 164(0.156) | 0.063 | 1.241(0.988–1.558) | 0.936 |
rs3731450 | Chk1 | 11 | A | 27(0.026) | 17(0.016) | 0.133 | 1.594(0.864–2.943) | 0.706 |
rs3731466 | Chk1 | 11 | T | 111(0.117) | 102(0.105) | 0.415 | 1.126(0.847–1.497) | 0.754 |
rs75219635 | Chk1 | 11 | C | 41(0.039) | 38(0.036) | 0.712 | 1.089(0.694–1.707) | 0.392 |
rs565435 | Chk1 | 11 | C | 242(0.229) | 241(0.228) | 0.959 | 1.005(0.821–1.232) | 0.720 |
rs74457900 | Cdc25C | 5 | A | 290(0.284) | 285(0.281) | 0.893 | 1.013(0.836–1.229) | 0.267 |
rs3734166 | Cdc25C | 5 | G | 409(0.389) | 396(0.374) | 0.493 | 1.063(0.892–1.268) | 0.984 |
rs6861656 | Cdc25C | 5 | T | 773(0.740) | 750(0.713) | 0.158 | 1.149(0.948–1.392) | 0.572 |
rs3756766 | Cdc25C | 5 | A | 163(0.160) | 120(0.120) | 0.011 | 1.392(1.080–1.794) | 0.239 |
rs16915503 | CDK1 | 10 | C | 35(0.033) | 32(0.031) | 0.801 | 1.065(0.654–1.733) | 0.029 |
rs139245206 | CDK1 | 10 | A | 99(0.094) | 89(0.084) | 0.453 | 1.122(0.831–1.514) | 0.324 |
rs2448343 | CDK1 | 10 | G | 840(0.797) | 836(0.792) | 0.763 | 1.033(0.836–1.276) | 0.442 |
rs3213031 | CDK1 | 10 | G | 90(0.086) | 77(0.074) | 0.288 | 1.187(0.865–1.630) | 0.915 |
rs3213032 | CDK1 | 10 | G | 963(0.912) | 942(0.890) | 0.097 | 1.275(0.957–1.698) | 0.052 |
rs2448345 | CDK1 | 10 | T | 927(0.883) | 919(0.874) | 0.515 | 1.091(0.840–1.417) | 0.306 |
rs3213046 | CDK1 | 10 | T | 893(0.852) | 888(0.843) | 0.541 | 1.077(0.849–1.366) | 0.181 |
rs2448347 | CDK1 | 10 | A | 759(0.720) | 743(0.702) | 0.366 | 1.091(0.904–1.317) | 0.818 |
rs3213048 | CDK1 | 10 | C | 381(0.365) | 367(0.348) | 0.405 | 1.079(0.902–1.290) | 0.669 |
rs1871445 | CDK1 | 10 | C | 669(0.636) | 660(0.629) | 0.726 | 1.032(0.864–1.232) | 0.789 |
rs3213082 | CDK1 | 10 | C | 1011(0.956) | 1007(0.954) | 0.827 | 1.047(0.695–1.576) | 0.396 |