A case of syphilis associated with immune reconstitution inflammatory syndrome and review of the literature

Table 2 Type of IRIS and clinical manifestation

Author	Type of Iris and Neurosyphilis/ ocular syphilis (yes or no)	Time to IRIS after starting ARVT (days)	Cutaneous manifestation (yes or no)	Genital lesion (yes or no)	Ocular manifestation (yes or no, type)	Lymphadenopathy (yes or no)	Systemic symptoms (yes or no)	Neurological symptoms (yes or no, type)	Other manifestation (yes or no, type)
Mitra et al. [3]	Unmasking, no	42	Yes	Yes	No	No	No	No	No
Alcedo et al. [8]	Paradoxical, yes	15	Yes	Yes	Yes, panuveitis	No	No	Yes, headache	No
Yap et al. [7]	Unmasking, yes	14	Yes (lues maligna)	No	Yes, vitritis	No	Yes	No	No
Frunza-Stefan et al. [11]	Unmasking, no	3	Yes	No	No	No	No	No	No
Braue et al.[4]	Unmasking, no	14	Yes, (lues maligna)	No	No	Yes	Yes	No	Yes, rectal mass
Khatri et al. [12]	Unmasking, no	28	Yes	No	No	No	No	No	No
Vasudevan et al. [9]	Unmasking, no	60	Yes	No	No	No	No	No	No
Bernal et al. [13]	Unmasking, yes	30	No	No	Yes, panuveitis	No	Yes	No	No
Hardwick et al. [14]	Paradoxical, yes	60	Yes	No	Yes, iritis	No	Yes	No	Yes, rhinitis
Moloney et al. [15]	Unmasking, yes	540	No	No	Yes, scleritis, retinitis and vitritis	Yes	No	Yes, headache	No
Brochard et al. [16]	Unmasking, no	3	Yes	No	No	No	Yes	No	Yes, left knee arthritis
Ceccarelli et al. [17]	Unmasking, yes	28	No	No	Yes, uveo-papillitis, retinal detachment	No	No	Yes, headache	No
Rushing et al. [5]	Paradoxical, yes	42	Yes	No	No	No	No	Yes, headache, word-finding difficulty and arm numbness	No
Bucher et al.[6]	Paradoxical, yes	10	Yes	No	No	No	No	Yes, meningovascular syphilis (headache, photophobia, ataxia, memory impairment and diplopia)	No
Our case	Paradoxical, yes	21	Yes	No	Yes, retinitis, iritis and vitritis	Yes	No	No	No

ISSN: 1742-6405