Table 1 List of hyperglycaemic cases
Sex and age | a.Suspected drug b.Strength c.Frequency of administration d.Indication | Treatment of ADR | Concomitant drug | ADR reported | Serious and seriousness criteria | Time to onset | Outcome of the ADR |
|---|---|---|---|---|---|---|---|
Female, 51 | a.Dolutegravir; Lamivudine; Tenofovir b.50 mg/300 mg/300 mg c.Once a day d.HIV infection | Metformin 500 mg | Isoniazid | Hyperglycaemia | Yes; hospitalization | 5 months | Recovering |
Female, 52 | a.Dolutegravir; Lamivudine; Tenofovir b.50/300 mg/300 mg c.Once day d.HIV infection | Metformin 500 mg and Glibenclamide 5 mg | Hyperglycaemia | Yes; hospitalization | 2 months | Recovering | |
Male, 64 | a.Abacavir; Dolutegravir; Lamivudine b.Once a day c.HIV infection | 1. Insulin and normal saline 2.Metformin 500 mg | Hyperglycaemia Blindness | Yes; hospitalization | 4 months | Recovering | |
Female, 52 | a.Dolutegravir; Lamivudine; Tenofovir b.50 mg/300 mg/300 mg c.Once a day d.HIV infection | Continued with Metformin and Glibenclamide | Metformin Glibenclamide | Hyperglycaemia Muscle spasms Dizziness | Yes; hospitalization | 3 months | Recovering |
Female, 57 | a.Dolutegravir; Lamivudine; Tenofovir b.50 mg/300 mg/300 mg c.Once a day d.HIV infection | Metformin 500 mg | Hydrochlorothiazide Acetylsalicylic acid | Hyperglycaemia | Yes; hospitalization | 4 months | Recovering |
Female,70 | a.Dolutegravir; Lamivudine; Tenofovir b.50 mg/300 mg/300 mg c.Once a day d.HIV infection | Metformin 500 mg | Atenolol Hydrochlorothiazide | Hyperglycaemia Muscle spasms | Yes; hospitalization | 3 months | Recovering |
Male, 58 | a.Dolutegravir; Lamivudine; Tenofovir b.50 mg/300 mg/300 mg c.Once a day d.HIV infection | Continued with Metformin 500 mg | Metformin 500 mg | Hyperglycaemia Muscle spasms | No | 3 months | Recovering |
Female | a.Dolutegravir; Lamivudine; Tenofovir b.50 mg/300 mg/300 mg c.Once a day d.HIV infection | •Insulin 12 IU •Infused with ringer lactate solution •Metformin 500 mg •Glibenclamide 5 mg | Hydrochlorothiazide Enalapril | Hyperglycaemia | Yes; hospitalization | 5 months | Recovering |