Attribute | Levels | Restrictions by mode of administration | ||||
---|---|---|---|---|---|---|
LA Oral | SC injection | IM injection | Implant | All modes | ||
Mode | LA Oral, SC Injection, IM Injection, Implant* | Â | Â | Â | Â | Â |
Frequency | 1, 4, 8, 12, 26, 52 weeks | 1 or 4 weeks | 1, 4, 8, or 12 weeks | 4, 8, or 12 weeks | 26 or 52 weeks | IF location = clinic or pharmacy, THEN dose frequency ≥ 4 |
Location | Home, pharmacy, clinic | Only home | Any | Not home | Only clinic | IF frequency = 1 week, THEN location = home |
Pain | None, mild, moderate | Only none | None or mild | Mild or moderate | Mild or moderate | Â |
Oral lead-in | 0, 3, 6Â months | Â | Â | Â | Â | Â |
Negative reaction testing | Yes or no | Â | Â | Â | Â | Â |
Late dose leeway | Short, long* | Â | Â | Â | Â | Â |