Table 3 Diagnostic performance of clinical variables for the diagnosis of histoplasmosis
Pancytopenia | < 50 CD4 cells/μL | AST levels > 46 IU/L | < 200 CD4 cells/μL | Elevated AST plus < 200 CD4 cells/μL | Pancytopenia plus < 50 CD4 cells/μL | |
|---|---|---|---|---|---|---|
Sensitivity | 42 | 73.5 | 80 | 95.9 | 100 | 84 |
Specificity | 88.5 | 59.1 | 50.5 | 15.7 | 11.7 | 57.4 |
Positive predictive value | 60 | 43.4 | 40.9 | 32.6 | 32.1 | 44.7 |
Negative predictive value | 78.8 | 84 | 85.5 | 90 | 100 | 89.7 |
Positive likelihood ratio | 3.65 | 1.8 | 1.62 | 1.14 | 1.13 | 1.97 |
Negative likelihood ratio | 0.66 | 0.45 | 0.4 | 0.26 | 0 | 0.28 |