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Table 1 Demographic, clinical and laboratory characteristics

From: Closing gaps in histoplasmosis: clinical characteristics and factors associated with probable/histoplasmosis in HIV/AIDS hospitalized patients, a retrospective cross-sectional study in two tertiary centers in Pereira, Colombia

 

Histoplasmosis group, n = 50 (%)

No histoplasmosis group, n = 122 (%)

P value

Male %

39(78)

92(75.4)

0.7

Age in years, median (IQR)

35 (29–46)

40 (29–54)

0.2

Days of hospital stay, median (IQR)

32 (17–48)

23 (14–38)

0.25

In-hospital mortality

14 (28)

29 (23)

0.56

Viral load (copies/mL), median (IQR)

289,000 (76,300–1,310,951)

265,454 (63,763–773,753)

0.12

CD4 (cells/μL), median (IQR)

28 (14–52)

73 (30–137)

0.002

< 50 CD4 cells/μL, %

36 (73.4)

47 (40.8)

0.001

AIDS category 1

0

5 (4.09)

0.32

AIDS category 2

2 (4.08)

13 (11)

0.23

AIDS category 3

47 (95)

97 (84)

0.03

AIDS category C

50 (100)

84 (68)

0.001

Antifungal treatment

47(94)

80 (65)

0.001

Other AIDS-related co-infections

 Tuberculosis

22 (44)

57 (46)

0.7

 Pneumocystis pneumonia

7 (14)

17(13)

0.9

 Toxoplasmosis

5 (10)

29 (23)

0.03

Symptoms and clinical characteristics

 Constitutional symptoms (weight loss, night sweats, with/without fever)

44 (88)

105 (86)

0.73

 Unintended weight loss

43 (86)

97 (79)

0.32

 Fever

40 (80)

89 (73)

0.33

 Diarrhea

33 (66)

75 (61)

0.58

 Cough

28 (56)

78 (63)

0.33

 Dyspnea

21 (42)

67 (54)

0.12

 Lymphadenopathy

22 (44)

63 (51)

0.36

 Headache

11 (22)

54 (44)

0.006

 Mucocutaneous lesions

16 (32)

49 (40)

0.31

 Shock and multiple organ dysfunction syndrome

13 (26)

18 (14)

0.08

 H-Score, median (IQR)

71 (40–95)

42 (37–75)

0.04

Laboratory abnormalities and imaging tests

 Ferritin levels > 1000 ng/mL

28 (77)

39 (56)

0.03

 ALP levels (IU/L). median (IQR)

366 (226–802)

173 (100–326)

0.003

 AST levels > 46 IU/L

36 (80)

52 (49)

0.001

 AST/ALT ratio > 2

20 (40)

22 (20)

0.003

 Leukocyte count in CBC (109/L), median (IQR)

3.3 (1.9–5.8)

5.7 (3.8–7.8)

0.001

 Platelet count in CBC (109/L), median (IQR)

131 (56–230)

230 (156–323)

0.009

 Pancytopenia

21 (42)

14 (11)

0.001

 Abnormal chest CT

38 (88)

66 (68)

0.014

  1. IQR interquartile range, ALP alkaline phosphatase, AST aspartate transaminase, ALT alanine transaminase, CBC complete blood count, CT computed tomography
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AIDS Research and Therapy

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