AIDS Research and Therapy

Table 3 Adjusted (aHR) Cox Hazard ratios for predictors of mortality in 343 PLWH with TB symptoms by Site

From: Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala

	Both Sites^a		Site 1^a		Site 2^a
	aHR	p value	aHR	p value	aHR	p value
Age^b
≤ 20	ref		ref		NA	NA
21–30	2.42 (0.29–20.17)	0.412	1.00 (0.12–8.43)	0.998	ref
31–40	2.26(0.27–18.53)	0.448	0.63 (0.07–5.30)	0.673	1.01 (0.30–3.46)	0.983
41–50	2.33 (0.28–19.06)	0.43	1.08 (0.13–8.69)	0.943	0.71 (0.16–3.06)	0.643
51–60	2.72 (0.31–24.20)	0.368	0.23 (0.01–3.91)	0.307	2.20 (0.56–8.66)	0.257
>60	1.43 (0.13–15.66)	0.957	0.69 (0.07–6.32)	0.741	NA	NA
Sex
Men	ref		ref		ref
Women	1.31 (0.65–2.61)	0.448	0.51 (0.14–1.87)	0.312	2.43 (1.09–5.43)	0.03
Diabetes^c
No	ref		ref		ref
Yes	0.67 (0.12–3.86)	0.658	NA	NA	0.52 (0.07–4.32)	0.543
BMI^d
≥ 17 kg/m²	ref		ref		ref
< 17 kg/m²	1.41 (0.72– 2.79)	0.317	0.58 (0.12–2.73)	0.495	2.77 (1.11–6.92)	0.029
ART^e
1st line	ref		ref		ref
2nd line	2.39 (1.12–5.07)	0.023	6.79 (2.16–21.31)	0.001	0.93 (0.42–2.05)	0.853
LAM
Negative	ref		ref		ref
Positive	1.98 (1.02–3.84)	0.044	1.08 (0.32–3.67)	0.897	2.10 (0.94–4.67)	0.069

NA Not applied due to sample size limitations
The following confounders were used for adjustment: Age, sex, CD4 values, cART, viral load values, and WHO HIV stage
^a Site = Site 1 includes UAI 1 = “Dr. Isaac Cohen Alcahé” UAI and Rodolfo Robles Hospital
Site 2 includes UAI 2 = “Dr. Carlos Rodolfo Mejía” UAI and Roosevelt Hospital
^b Age was used as a continuous variable in the multivariable Cox regression for “Dr. Carlos Rodolfo Mejía-Villatoro” UAI
^c Hba1c measurements in % above 6.15 were considered the threshold for diabetic patients
^d In kg/m²
^e1st and 2nd line regimens are shown in Table 1

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ISSN: 1742-6405

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