Table 2 Sensitivity and specificity comparisons of LAM test after α-mannosidase treatment of urine vs. LAM test by Site and CD4 values using a composite gold standard
LAM after α-mannosidase treatment of urine | LAM alone | p valueb | LAM after α-mannosidase treatment of urine | LAM alone | p valueb | |||||
|---|---|---|---|---|---|---|---|---|---|---|
All CD4 values | Sensitivity (% (95% CI) | Sensitivity (% (95% CI) | Specificity (% (95% CI) | Specificity (% (95% CI) | ||||||
Positive/N | Positive/N | Negative/N | Negative/N | |||||||
Both Sitesa | 37/59 | 56.9 (44–69.2) | 37/59 | 55.2 (42.6–67.4) | 1 | 204/232 | 90.3 (85.6–93.8) | 202/232 | 90.2 (85.5–93.7) | 0.946 |
Site1 | 26/41 | 52 (37.4–66.3) | 26/41 | 49.1 (35.1–63.2) | 1 | 194/218 | 92.8 (88.4–95.9) | 191/218 | 92.7 (88.3–95.9) | 0.944 |
Site 2 | 11/18 | 73.3 (44.9–92.2) | 11/18 | 78.6 (49.2–95.3) | 1 | 10/14 | 58.8 (32.9–81.6) | 11/14 | 61.1 (35.7–82.7) | 1 |
LAM after α-mannosidase treatment of urine | LAM alone | LAM after α-mannosidase treatment of urine | LAM alone | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
CD4 values < 200 | Sensitivity (% (95% CI) | Sensitivity (% (95% CI) | p valueb | Specificity (% (95% CI) | Specificity (% (95% CI) | p valueb | ||||
Positive/N | Positive/N | Negative/N | Negative/N | |||||||
Both Sitesa | 27/39 | 60 (44.3–74.3) | 28/39 | 62.2 (46.5–76.2) | 1 | 95/113 | 88.8 (81.2–94.1) | 96/113 | 89.7 (82.3–94.8) | 1 |
Site1 | 16/27 | 53.3 (34.3–71.7) | 17/27 | 54.8 (36–72.7) | 1 | 88/102 | 88.9 (81–94.3) | 88/102 | 89.8 (82–95) | 1 |
Site 2 | 11/12 | 73.3 (44.9–92.2) | 11/12 | 78.6 (49.2–95.3) | 1 | 7/11 | 87.5 (47.3–99.7) | 8/11 | 88.9 (51.8–99.7) | 1 |