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Table 4 Cox analysis of risk factors for the death of HIV/AIDS patients on ART

From: Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in Southwestern China: a retrospective cohort study

Variable

n

Univariate analysis

P

Multivariate analysis

P

ADE

     

 No

5618

1.00

 

1.00

 

 Yes

1139

1.618 (1.356–1.931)

< 0.001

1.291 (1.061–1.571)

0.011

Age

  

< 0.001

 

< 0.001

 ≤ 40

1210

1.00

 

1.00

 

 40 < age ≤ 65

3734

2 (1.664–2.404)

< 0.001

2.068 (1.699–2.518)

< 0.001

 > 65

915

3.927 (3.191–4.831)

< 0.001

3.653 (2.896–4.607)

< 0.001

Gender

 Male

4619

1.00

 

1.00

 

 Female

2138

0.475 (0.394–0.574)

< 0.001

0.563 (0.463–0.686)

< 0.001

Marital status

  

0.027

 

0.069

 Unmarried

715

1.00

 

1.00

 

 Married or living with a partner

5026

1.171 (0.893–1.536)

0.253

0.737 (0.551–0.985)

0.039

 Divorced or widowed or other

1016

1.462 (1.071–1.994)

0.017

0.845 (0.601–1.187)

0.331

Route of HIV infection

  

0.372

  

 Blood or plasma transfusion

352

1.00

   

 Sexually transmitted

6104

1.205 (0.926–1.568)

0.166

  

 Other or unknown

301

1.139 (0.757–1.714)

0.533

  

WHO clinical stage

  

< 0.001

 

< 0.001

 I

2510

1.00

 

1.00

 

 II

1132

0.954 (0.733–1.242)

0.727

0.863 (0.7061.055)

0.150

 III

1863

1.057 (0.847–1.319)

0.625

1.095 (0.838–1.430)

0.506

 IV

1218

1.624 (1.281–2.058)

< 0.001

1.454 (1.092–1.935)

0.01

Previous use of the cotrimoxazole

     

 Yes

1879

1.00

 

1.00

 

 No

4878

0.406 (0.34–0.486)

< 0.001

0.4880.403–0.592

< 0.001

Initial antiretroviral regimen

  

< 0.001

 

< 0.001

 2NRTIs + 1NNRTI

5943

1.00

 

1.00

 

 2NRTIs + 1PI

517

6.212 (4.762–8.103)

< 0.001

4.721 (3.577–6.23)

< 0.001

 Single or two drugs

297

1.122 (0.844–1.49)

0.428

1.163 (0.87–1.555)

0.307

Baseline CD4+ cell count (cells/μL)

  

< 0.001

 

< 0.001

 CD4 ≥ 350

835

1.00

 

1.00

 

 200 ≤ CD4 < 350

1796

0.742 (0.442–1.247)

0.260

0.794 (0.468–1.345)

0.39

 100 ≤ CD4 < 200

1430

1.263 (0.762–2.095)

0.365

1.244 (0.739–2.094)

0.41

 50 ≤ CD4 < 100

796

1.484 (0.886–2.487)

0.134

1.56 (0.911–2.669)

0.11

 CD4 < 50

1900

1.898 (1.162–3.103)

0.011

1.846 (1.095–3.114)

0.02

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AIDS Research and Therapy

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