Time to start ART |
 Deferred until 5 weeks after the start of antifungal therapy |
ART regimen |
 Consider drug–drug interactions between fluconazole and antiretroviral agents |
  Fluconazole may potentially increase PI concentrations, but no clinical significance |
  Fluconazole has the potential to increase NNRTI concentration |
   No significant interactions with efavirenz |
   Nevirapine has the most potential clinical relevancea |
   No significant interactions with rilpivirine |
 Monitor closely for nevirapine-associated adverse events, including hepatotoxicity |