Total Lymphocyte Count as surrogate marker for CD4 Cell Count in HIV-Infected Individuals in Gondar University Hospital, Northwest Ethiopia

Table 3 Validity and predictive value between CD4 count and TLC among HIV infected patients in different age categories at Gondar University Hospital, 2011

Age	Marker	N	P	SE	SP	PPV	NPV	Kappa	P - value
In all age group	CD4 count ≤ 200 cell/μL	143	35.8	100	100	100	100	0.24	0.001
In all age group	TLC ≤ 1200 cell/μL	59	14.8	32.86	95.33	79.66	71.85	0.24	0.001
18-29	CD4 count ≤ 200 cell/μL	36	9.0	100	100	100	100
18-29	TLC ≤ 1200 cell/μL	12	3.0	22.22	95.65	66.66	75.86	0.22	0.002
30-39	CD4 count ≤ 200 cell/μL	66	16.5	100	100	100	100
30-39	TLC ≤ 1200 cell/μL	33	8.2	39.39	92.92	78.78	69.69	0.35	0.000
40-49	CD4 count ≤ 200 cell/μL	26	6.5	100	100	100	100
40-49	TLC ≤ 1200 cell/μL	12	3.0	26.92	90.74	58.33	72.05	0.20	0.038
50 & above	CD4 count ≤ 200 cell/μL	16	4.0	100	100	100	100
	TLC ≤ 1200 cell/μL	7	1.8	43.75	100	100	55	0.38	0.011

Abbreviation: N, number; P, Prevalence (%); SE, Sensitivity (%); SP, Specificity (%); PPV, Positive predictive value; NPV, Negative predictive value; CD4, T-lymphocyte CD4 positive; TLC, Total lymphocyte count; HIV, Human Immunodeficiency virus.

ISSN: 1742-6405