Table 4 Physical properties of the four rectal microbicide placebos
Viscositya | Gel Strength b | Adhesionb | Osmolarity | Condom Compability (puncture strength) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Product | Appearance | cps | pH | Lubricated | Non-lubricated | Standard ASTM method | ||||||
25°C | 37°C | mN | mN•sec | mmol/kg | 15 Min | 30 Min | 15 Min | 30 Min | ||||
Lipid Gel* | White, creamy, rigid semi-solid | 5634 | 2719 | 196.0 ± 2.0 | 127.4 ± 13.9 | NR | NR | 0.95 ↑ | -6.1↔ | 32.8 ↑ | 25.8 ↑ | Fail |
Lipid Fluid* | Clear, colourless, easily spreadable liquid | 5 | 4 | NRc | NR | NR | NR | 23.0 ↑ | 23.6 ↑ | 26.5 ↑ | 25.0 ↑ | Fail |
Aqueous Gel* | Transparent colourless gel | 5613 | 5225 | 21.3 ± 0.2 | 31.9 ± 7.8 | 324 ± 15 | 7.2 | 33.8 ↑ | 30.1↑ | 18.8 ↑ | 27.5 ↑ | Pass |
Aqueous Fluid* | transparent colourless liquid | 94 | 4136 | NR | NR | 402 ± 8 | 7.0 | 39.9 ↑ | 32.9 ↑ | 21.0 ↑ | 22.3 ↑ | Pass |
Water (negative control) | 22.3 ↑ | 20.2 ↑ | 14.8 ↑ | 15.3 ↑ | ||||||||
Mineral Oil (positive control) | -46.6 ↓ | -59.2 ↓ | -51.0 ↓ | -56.3 ↓ | ||||||||