Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture

Table 2 Time to viral rebound to the level of untreated virus control at 24 h

Inhibitor	Viral rebound (hours post wash)^a
	5 × EC₅₀^b	50 × EC₅₀^b
4'-Ed4T	>48	>>72
LFD4C	48	n.d
DDI	>72	n.d
D4T	<24	>72
FTC	48	n.d
3TC	<24	48
NVP	<24	<24
AZT	<24	<24

^a Luciferase activity similar to that on day 1 of the untreated virus control was considered as viral rebound.
^bEC₅₀ based on values without preincubation.
n.d (not determined): The inhibitors were not tested at these concentrations either because of known cytotoxicity or unachievable concentration during therapy of HIV-infected individuals.
Results are the average of at least three independent experiments.

ISSN: 1742-6405