The development of drug resistance mutations K103N Y181C and G190A in long term Nevirapine-containing antiviral therapy

Table 5 Correlated mutations in Single Genome Amplification dataset

	Position1	Mutation type	Position2	Ckaks	Lod
ART for 12 months
	K103N	NRTI	D67N	5	2.93
			T69D	8	Inf
			K70R	16	9.37
		NNRTI	Y181C	26	15.23
		NNRTI	H221Y	17	9.96
	Y181C	NRTI	D67N	5	2.93
			T69D	8	Inf
			K70R	1.12	5.27
		NNRTI	K103N	2	29.44
		NNRTI	H221Y	17	9.96
	G190A	NRTI	None
		NNRTI	K101E	29	16.98
ART for over 60 months	K103N	NRTI	T69D	12	Inf
		NNRTI	K219R	88	6.75
	Y181C	NRTI	D67N	11.5	14.12
		NRTI	T69D	2	Inf
		NNRTI	K103N	2.25	9.41
		NNRTI	H221Y	26	15.96
	G190A	NRTI	M41L	21.25	88.84
			D67N	7.33	13.51
			T69D	12	Inf
		NNRTI	K101E	13.8	42.37
			K103N	12	11.47
			Y181C	6.67	24.56
			H221Y	3.33	12.28

Note: Ckaks indicates the ka/ks ratio of two mutations. Here, it stands for the ka/ks ratio for M184V and the correlated mutations.
Lod is the confident score for positive selection, If LOD >2, the positive selection is significant.
Inf indicates the maximum infinity.

ISSN: 1742-6405