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  1. Anti-retroviral therapy regimen discontinuations become a big challenge and cause diminishing the clinical and immunological benefit of treatment in Ethiopia. It reduces both the duration and the chance of vir...

    Authors: Tewodros Getnet Amera, Kassawmar Angaw Bogale and Yibekal Manaye Tefera
    Citation: AIDS Research and Therapy 2021 18:93
    Content type: Research Published on:

  2. This study aims to evaluate the safety of inactivated COVID-19 vaccine among adult people living with HIV (PLWH). In total, 259 PLWH who received at least one dose of inactivated COVID-19 vaccine were enrolled...

    Authors: Songjie Wu, Yubin Zhang, Fangzhao Ming, Shi Zou, Mengmeng Wu, Wei Guo, Weiming Tang and Ke Liang
    Citation: AIDS Research and Therapy 2021 18:92
    Content type: Short Report Published on:

  3. Adolescents are lagging behind in the “third 95” objective of the Joint United Nations Program on HIV/AIDS requiring 95% of individuals on antiretroviral therapy (ART) to have viral load (VL) suppression. This...

    Authors: Joel Maena, Aduragbemi Banke-Thomas, Nelson Mukiza, Cynthia Ndikuno Kuteesa, Ronald Makanga Kakumba, Hajira Kataike, Samuel Kizito, Juliet Allen Babirye and Rita Nakalega
    Citation: AIDS Research and Therapy 2021 18:91
    Content type: Research Published on:

  4. Disseminated Mycobacterium avium complex infection is an important indicator of acquired immunodeficiency syndrome (AIDS) in patients with advanced human immunodeficiency virus (HIV) infection. Effective antiretr...

    Authors: Keiji Konishi, Hidenori Nakagawa, Akio Nakahira, Takahiro Okuno, Takeshi Inoue and Michinori Shirano
    Citation: AIDS Research and Therapy 2021 18:90
    Content type: Case Report Published on:

  5. Increased availability of HIV care over the past decade has dramatically reduced morbidity and mortality among people living with HIV (PLWH) in sub-Saharan Africa. However, perceived and experienced barriers t...

    Authors: Nancy Somi, Nicole Dear, Domonique Reed, Ajay Parikh, Anange Lwilla, Emmanuel Bahemana, Samoel Khamadi, Michael Iroezindu, Hannah Kibuuka, Jonah Maswai, Trevor A. Crowell, John Owuoth, Lucas Maganga, Christina Polyak, Julie Ake and Allahna Esber
    Citation: AIDS Research and Therapy 2021 18:89
    Content type: Research Published on:

  6. World Health Organization (WHO) reports that people who indulge in risky behaviours such as penile-anal sex, unprotected intercourse, multiple sex partners, and alcohol and illicit drugs are at risk of HIV/AID...

    Authors: Olawale Durosinmi-Etti, Emmanuel Kelechi Nwala, Funke Oki, Akudo Ikpeazu, Emmanuel Godwin, Paul Umoh, Arome Shaibu, Alex Ogundipe and Abiye Kalaiwo
    Citation: AIDS Research and Therapy 2021 18:88
    Content type: Research Published on:

  7. Events associated with the COVID-19 pandemic, such as physical distancing, closure of community services, postponement of health appointments, and loss of employment can lead to social isolation, financial unc...

    Authors: Kelly K. O’Brien, Ahmed M. Bayoumi, Soo Chan Carusone, Aileen M. Davis, Rachel Aubry, Lisa Avery, Patricia Solomon, Kristine M. Erlandson, Colm Bergin, Richard Harding, Darren A. Brown, Jaime H. Vera and Steven E. Hanna
    Citation: AIDS Research and Therapy 2021 18:87
    Content type: Research Published on:

  8. Thoracic actinomycosis is an uncommon, chronic, and progressive infection, especially in patients with HIV. We report a case of thoracic actinomycosis presenting as an isolated pleural effusion in a patient wi...

    Authors: Jung Wan Park, Yon Hee Kim, Eunjung Lee, Se Yoon Park and Tae Hyong Kim
    Citation: AIDS Research and Therapy 2021 18:86
    Content type: Case Report Published on:

  9. Programmes that merge management of Human Immunodeficiency Virus (HIV) and tuberculosis (TB) aim to improve HIV/TB co-infected patients’ access to comprehensive treatment. However, several reports from sub-Sah...

    Authors: Benjamin Momo Kadia, Christian Akem Dimala, Noah T. Fongwen and Adrian D. Smith
    Citation: AIDS Research and Therapy 2021 18:85
    Content type: Research Published on:

  10. In 2007–2012 the Mexican government launched the National HIV program and there was a major change in HIV policies implemented in 2013–2018, when efforts focused on prevention, increase in early diagnosis and ...

    Authors: Amilcar Azamar-Alonso, Sergio A. Bautista-Arredondo, Fiona Smaill, Lawrence Mbuagbaw, Andrew P. Costa and Jean-Eric Tarride
    Citation: AIDS Research and Therapy 2021 18:84
    Content type: Research Published on:

  11. Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general po...

    Authors: Ika Prasetya Wijaya, Birry Karim, Mohamad Syahrir Azizi, Ibnu Ariyanto, Arif Mansjoer, Evy Yunihastuti, Kuntjoro Harimurti, Idrus Alwi, Silvia Lee and Patricia Price
    Citation: AIDS Research and Therapy 2021 18:83
    Content type: Short Report Published on:

  12. To evaluate the effect of reconstruction and repair, using a mini-plate and bone graft for HIV -positive patients with giant cell tumor of long bone.

    Authors: Biao Xu, Rui Ma, Wen-sheng Zhang, Qiang Zhang, Chang-song Zhao and Jie Wang
    Citation: AIDS Research and Therapy 2021 18:82
    Content type: Research Published on:

  13. Socioeconomic, demographic and clinical factors can affect adherence to treatment among people living with HIV (PLH) and potentially have an impact on their prognosis and survival. The main objective of this s...

    Authors: Ludentz Dorcélus, Joseph Bernard Jr., Constant Georgery and Clerveau Vanessa
    Citation: AIDS Research and Therapy 2021 18:81
    Content type: Research Published on:

  14. The efficacy and tolerability of an antiretroviral regimen are important considerations for selection of HIV-1 infection maintenance therapy. Abacavir/lamivudine plus rilpivirine (ABC/3TC + RPV) has been shown...

    Authors: Z. C. Lim, G. S. Hoo, J. H. Ang, C. B. Teng, L. W. Ang, C. C. Lee, Y. S. Leo, H. L. Law, O. T. Ng and C. S. Wong
    Citation: AIDS Research and Therapy 2021 18:80
    Content type: Research Published on:

  15. Viral suppression prevents HIV transmission and disease progression, but socio-economic and clinical factors can hinder the goal of suppression. We evaluated factors associated with viral non suppression (VNS)...

    Authors: Dean W. Ortíz, Olivia Roberts-Sano, Hugo E. Marroquin, Lindsey Larson, Katherine B. Franco, Andrej Spec, Johanna R. Melendez, Rodolfo Pinzón, Ana J. Samayoa, Carlos Mejia-Chew and Jane A. O´Halloran
    Citation: AIDS Research and Therapy 2021 18:79
    Content type: Research Published on:

  16. Symptoms of primary HIV infection, including fever, rash, and headache, are nonspecific and are often described as flu-like. COVID-19 vaccination side effects, such as fever, which occur in up to 10% of people...

    Authors: Julian Triebelhorn, Stefanie Haschka, Felix Hesse, Johanna Erber, Simon Weidlich, Marcel Lee, Dieter Hoffmann, Josef Eberle and Christoph D. Spinner
    Citation: AIDS Research and Therapy 2021 18:78
    Content type: Case Report Published on:

  17. Targeting RNA is a promising yet underdeveloped modality for the selective killing of cells infected with HIV-1. The secretory ribonucleases (RNases) found in vertebrates have cytotoxic ribonucleolytic activit...

    Authors: Ian W. Windsor, Dawn M. Dudley, David H. O’Connor and Ronald T. Raines
    Citation: AIDS Research and Therapy 2021 18:77
    Content type: Research Published on:

  18. AIDS-related primary central nervous system lymphoma (AR-PCNSL) is an AIDS-defining disease that usually occurs when the CD4 count is less than 50 cells/μl. The frequency of the disease has substantially decre...

    Authors: Pieter-Jan Gijs and Olivier Clerc
    Citation: AIDS Research and Therapy 2021 18:76
    Content type: Case Report Published on:

  19. An increasing number of HIV cure trials involve combining multiple potentially curative interventions. Until now, considerations for designing and implementing complex combination HIV cure trials have not been...

    Authors: Karine Dubé, John Kanazawa, Lynda Dee, Jeff Taylor, John A. Sauceda, Sara Gianella, Davey Smith, Steven G. Deeks and Michael J. Peluso
    Citation: AIDS Research and Therapy 2021 18:75
    Content type: Research Published on:

  20. Introduction of tenofovir (TDF) plus lamivudine (3TC) and dolutegravir (DTG) in first- and second-line HIV treatment regimens in South Africa warrants characterization of acquired HIV-1 drug resistance (ADR) m...

    Authors: Benjamin Chimukangara, Richard J. Lessells, Lavanya Singh, Indra Grigalionyte, Nonhlanhla Yende-Zuma, Rochelle Adams, Halima Dawood, Linda Dlamini, Sibonisile Buthelezi, Sheldon Chetty, Karidia Diallo, Wayne A. Duffus, Mary Mogashoa, Melissa B. Hagen, Jennifer Giandhari, Tulio de Oliveira…
    Citation: AIDS Research and Therapy 2021 18:74
    Content type: Research Published on:

  21. A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection.

    Authors: Pedro Vieira Bertozzi, Amanda de Oliveira Vicente, Amanda Siqueira Pereira, Joao Pedro Espinha de Sant’Ana, Rafaela Braga Cabrera Mano, Luciana Souza Jorge and Rodrigo Afonso da Silva Sardenberg
    Citation: AIDS Research and Therapy 2021 18:73
    Content type: Case Report Published on:

  22. The growing burden of the HIV and non-communicable disease (NCD) syndemic in Sub- Saharan Africa has necessitated introduction of integrated models of care in order to leverage existing HIV care infrastructure...

    Authors: Blessings Gausi, Natacha Berkowitz, Nisha Jacob and Tolu Oni
    Citation: AIDS Research and Therapy 2021 18:72
    Content type: Research Published on:

  23. The availability and accessibility of effective antiretroviral therapy (ART) for people living with HIV (PLWH) has substantially improved in the past two decades in resource-limited settings. Therefore, evalua...

    Authors: Weerawat Manosuthi, Lantharita Charoenpong and Chalor Santiwarangkana
    Citation: AIDS Research and Therapy 2021 18:71
    Content type: Research Published on:

  24. Medical care re-engagement is critical to suppressing viral load and preventing HIV transmission, morbidity and mortality, yet few rigorous intervention studies address this outcome. We assessed the effectiven...

    Authors: Mary K. Irvine, McKaylee M. Robertson, Denis Nash, Sarah G. Kulkarni, Sarah L. Braunstein and Bruce Levin
    Citation: AIDS Research and Therapy 2021 18:70
    Content type: Short Report Published on:

  25. The current standard of care is to start antiretroviral therapy in all patients diagnosed with HIV-1, as for HIV-2 current DHHS guideline suggests ART for HIV-2 as soon as diagnosis is established, although th...

    Authors: Margarida Cardoso, Joana Vasconcelos, Teresa Baptista, Isabel Diogo, Fátima Gonçalves, Kamal Mansinho and Perpétua Gomes
    Citation: AIDS Research and Therapy 2021 18:69
    Content type: Case Report Published on:

  26. Men who have sex with men (MSM) are potentially at high risk for HIV infection, their HIV prevalence far exceeds the national prevalence rate. There are also a number of MSM who have sex with women, mostly unp...

    Authors: Huan Zhao, Xi Li, Junhua Wang, Wen Wang, Chunyan Yang, Jingjuan Li, Xiuling Li, Rui Pu, Lulu Chen, Xiao Zhang, Jun Zhang, Peng Luo and Jiangping Zhang
    Citation: AIDS Research and Therapy 2021 18:68
    Content type: Review Published on:

  27. Men who have Sex with Men (MSM) represent the risk group that are disproportionately most affected by the human immunodeficiency virus (HIV) and continue to drop-off from the steps of the continuum of HIV serv...

    Authors: Willy Dunbar, Marie Colette Alcide Jean-Pierre, Jacky S. Pétion, Aline Labat, Nathalie Maulet and Yves Coppieters
    Citation: AIDS Research and Therapy 2021 18:67
    Content type: Research Published on:

  28. Achieving undetectable viral load is crucial for the reduction of HIV transmissions, AIDS-related illnesses and death. Adolescents (10 to19 years) living with HIV (ALHIV) on antiretroviral treatment (ART) have...

    Authors: Emeka F. Okonji, Brian van Wyk, Ferdinand C. Mukumbang and Gail D. Hughes
    Citation: AIDS Research and Therapy 2021 18:66
    Content type: Research Published on:

  31. Reduction of the reservoir of latent HIV-infected cells might increase the possibility of long-term remission in individuals living with HIV. We investigated factors associated with HIV-1 proviral DNA levels i...

    Authors: Helen Payne, Man K. Chan, Sarah A. Watters, Kennedy Otwombe, Nei-Yuan Hsiao, Abdel Babiker, Avy Violari, Mark F. Cotton, Diana M. Gibb and Nigel J. Klein
    Citation: AIDS Research and Therapy 2021 18:63
    Content type: Research Published on:

  32. To accelerate progress toward the UNAIDS 90-90-90 targets, US Centers for Disease Control and Prevention Nigeria country office (CDC Nigeria) initiated an Antiretroviral Treatment (ART) Surge in 2019 to identi...

    Authors: Andrew T. Boyd, Ibrahim Jahun, Emilio Dirlikov, Stacie Greby, Solomon Odafe, Alhassan Abdulkadir, Olugbenga Odeyemi, Ibrahim Dalhatu, Obinna Ogbanufe, Andrew Abutu, Olugbenga Asaolu, Moyosola Bamidele, Chibuzor Onyenuobi, Timothy Efuntoye, Johnson O. Fagbamigbe, Uzoma Ene…
    Citation: AIDS Research and Therapy 2021 18:62
    Content type: Research Published on:

  33. This study investigates the willingness of men-who-have-sex-with-men (MSM) to use HIV pre-exposure prophylaxis (PrEP). Research in the HIV/AIDS field typically relies on clinical and epidemiological studies, t...

    Authors: Michele Pazzini, Zsófia S. Ignácz and Julia Tuppat
    Citation: AIDS Research and Therapy 2021 18:61
    Content type: Research Published on:

  34. Mental health problems (e.g., depression and anxiety) are among the most commonly reported comorbidities of HIV. Antiretroviral therapy (ART) coverage has increased sharply. The purposes of this prospective co...

    Authors: Jinzhao Xie, Zixin Wang, Quanmin Li, Qiangsheng He, Guohong Xu, Yonghong Li, Kai Zhou, Linghua Li and Jing Gu
    Citation: AIDS Research and Therapy 2021 18:60
    Content type: Research Published on:

  35. We estimated the predictive effects of ART-related perceptions on the actual ART uptake behavior among ART naïve PLWH stratified by different time of HIV diagnosis under the new strategy.

    Authors: Tinglong Yang, Xueying Yang, Linghua Li, Huifang Xu, Lirui Fan, Quanmin Li, Xiaoyan Fan, Weiyi Chen, Xuan Du, Chun Hao, Jinghua Li, Yuantao Hao and Jing Gu
    Citation: AIDS Research and Therapy 2021 18:59
    Content type: Research Published on:

  36. The DUALIS study showed that switching to boosted darunavir (bDRV) plus dolutegravir (DTG; 2DR) was non-inferior to continuous bDRV plus 2 nucleoside/nucleotide reverse-transcriptase inhibitors (NRTIs; 3DR) in...

    Authors: Eva Wolf, Christoph Boesecke, Annamaria Balogh, Helen Bidner, Christiane Cordes, Hans Heiken, Ivanka Krznaric, Tim Kümmerle, Hans-Jürgen Stellbrink, Jochen Schneider and Christoph D. Spinner
    Citation: AIDS Research and Therapy 2021 18:58
    Content type: Short Report Published on:

  37. Although individual antiretroviral drugs have been shown to be associated with elevated cardiovascular disease (CVD) risk, data are limited on the role of antiretroviral drug combinations. Therefore, we sought...

    Authors: Kunchok Dorjee, Manisha Desai, Tsering Choden, Sanjiv M. Baxi, Alan E. Hubbard and Arthur L. Reingold
    Citation: AIDS Research and Therapy 2021 18:57
    Content type: Research Published on:

  38. We report a case of sudden, lethal metabolic acidosis in a 70-year-old man on long-term nucleoside reverse transcriptase inhibitor (NRTI) -based antiretroviral therapy (ART) who had developed atypical necrotiz...

    Authors: Alexa Hollinger, Nadine Cueni, Catia Marzolini, Michael Dickenmann, Emmanuelle Landmann, Manuel Battegay, Aurélien Emmanuel Martinez, Martin Siegemund and Anne Leuppi-Taegtmeyer
    Citation: AIDS Research and Therapy 2021 18:56
    Content type: Case Report Published on:

  39. For over a decade, antiretroviral therapy (ART) in resource-limited countries was only recommended for patients with advanced HIV disease. We investigated this group of patients in order to determine any relat...

    Authors: Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George P. Judicate, Bruno Sunguya, Eligius Lyamuya and Takamasa Ueno
    Citation: AIDS Research and Therapy 2021 18:55
    Content type: Research Published on:

  40. A North–South (N–S) research collaboration is one way through which research capacity of developing countries can be strengthened. Whereas N–S collaboration in HIV/AIDS area may result in research capacity str...

    Authors: Hesborn Wao, Yan Wang, Melvin A. Wao and Juliana A. Were
    Citation: AIDS Research and Therapy 2021 18:54
    Content type: Research Published on:

  41. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has become the preferred drug for the treatment of HIV-1 and chronic hepatitis B infection in clinical practice. Results from clinical trials sh...

    Authors: Thornthun Ueaphongsukkit, Sivaporn Gatechompol, Anchalee Avihingsanon, Jerasit Surintrspanont, Kroonpong Iampenkhae, Yingyos Avihingsanon and Suwasin Udomkarnjananun
    Citation: AIDS Research and Therapy 2021 18:53
    Content type: Case Report Published on:

  42. HIV and hepatitis C virus (HCV) have shared routes of transmission among men who have sex with men (MSM). Routine testing facilitates early diagnosis and treatment, thereby preventing morbidity and onward tran...

    Authors: Trevor A. Crowell, Haoyu Qian, Carsten Tiemann, Clara Lehmann, Christoph Boesecke, Albrecht Stoehr, Jukka Hartikainen, Stefan Esser, Markus Bickel, Christoph D. Spinner, Stephan Schneeweiß, Christiane Cordes, Norbert Brockmeyer, Heiko Jessen, Merlin L. Robb, Nelson L. Michael…
    Citation: AIDS Research and Therapy 2021 18:52
    Content type: Short Report Published on:

  43. The HIV pandemic continues to cause a high burden of morbidity and mortality due to delayed diagnosis. Histoplasmosis is prevalent in Latin America and Colombia, is difficult to diagnose and has a high mortali...

    Authors: Julián Andrés Hoyos Pulgarin, John Alexander Alzate Piedrahita, German Alberto Moreno Gómez, Juan Felipe Sierra Palacio, Karen Melissa Ordoñez and Deving Arias Ramos
    Citation: AIDS Research and Therapy 2021 18:51
    Content type: Research Published on:

  44. There is a growing recognition of the impact of gender and the social determinants of health on the clinical course of people living with HIV (PLHIV). However, the relative contribution of these factors to cli...

    Authors: Phyo Pyae Nyein, Eithandee Aung, Ne Myo Aung, Mar Mar Kyi, Mark Boyd, Kyaw Swar Lin and Josh Hanson
    Citation: AIDS Research and Therapy 2021 18:50
    Content type: Short Report Published on:

  46. In sub-Saharan African countries Epstein Barr virus (EBV) infection occurs in early childhood. We aim to investigate the factors associated with EBV acquisition and the impact of EBV infection on the humoral r...

    Authors: Silvia Baroncelli, Clementina Maria Galluzzo, Giuseppe Liotta, Mauro Andreotti, Stefano Orlando, Fausto Ciccacci, Robert Mphwere, Richard Luhanga, Jean Baptiste Sagno, Roberta Amici, Maria Cristina Marazzi and Marina Giuliano
    Citation: AIDS Research and Therapy 2021 18:48
    Content type: Research Published on:

  47. HIV is an infectious disease affecting 36.7 million people worldwide. In recent times, Antiretroviral Therapy (ART) has become accessible to the majority of People Living with HIV (PLHIV) and this has transfor...

    Authors: Archana Ganapathy, Basavaprabhu Achappa, Vaman Kulkarni, Deepak Madi, Ramesh Holla, Unnikrishnan Bhaskaran, Priya Rathi, Soundarya Mahalingam and Nikhil Victor Dsouza
    Citation: AIDS Research and Therapy 2021 18:47
    Content type: Research Published on:

  48. HIV pre-exposure prophylaxis (PrEP) is a key component of HIV combination prevention strategies and has the potential to decrease the incidence of HIV in men who have sex with men (MSM). This study aimed to ev...

    Authors: Yuansheng Fu, Akililu Alemu Ashuro, Xianxiang Feng, Ting Wang, Sichen Zhang, Dongqing Ye and Yinguang Fan
    Citation: AIDS Research and Therapy 2021 18:46
    Content type: Research Published on:

  49. The prevalence of Human Immunodeficiency Virus (HIV) among adults and children in Uganda is 6.2% and 0.5% respectively. The prevalence of viral load suppression in Uganda among all adults and children living w...

    Authors: Atwau Pius, Najjuma Nambi Josephine, Sibo Erick, Agoa Winifred, Mukashyaka Rita, Okoli Silverjoseph, Ezatiru Lucy and Nyemara Novatus
    Citation: AIDS Research and Therapy 2021 18:45
    Content type: Research Published on:

  50. This study compares the management and outcome of high grade squamous intraepithelial lesions (HSIL) in HIV-positive and -negative women and identifies risk factors for treatment failure.

    Authors: Christine Gilles, Maude Velghe-lenelle, Yannick Manigart, Déborah Konopnicki and Serge Rozenberg
    Citation: AIDS Research and Therapy 2021 18:44
    Content type: Research Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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